RT Journal Article SR Electronic T1 â–¼Mirabegron for overactive bladder syndrome JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 90 OP 92 DO 10.1136/dtb.2013.8.0196 VO 51 IS 8 YR 2013 UL http://dtb.bmj.com/content/51/8/90.abstract AB Urinary incontinence, the involuntary leakage of urine, can result from abnormalities of the urinary tract or may be caused by other conditions and is sub-divided into a number of classifications including stress incontinence and urge urinary incontinence.1 Urge urinary incontinence (UUI) is involuntary urine leakage accompanied by urgency of micturition.2 Overactive bladder (OAB) syndrome is defined as urgency occurring with or without UUI and usually occurs with frequency and nocturia.1 Wet OAB is associated with UUI, while dry OAB is not associated with incontinence. Current drug therapy for OAB involves the use of an antimuscarinic drug, of which there are a number available, such as oxybutynin, darifenacin, solifenacin and tolterodine.1,3 â–¼Mirabegron is the first of a new class of drug, beta-3-adrenoreceptor agonists, licensed for symptomatic treatment of urgency, increased micturition frequency and/or urgency incontinence as may occur in adult patients with OAB syndrome.4 Here we review the evidence for mirabegron.