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Fluorouracil cream (efudix) in dermatology


Fluorouracil is a cytotoxic drug synthesised in 1957.1 When it was given systemically to patients with leukaemia who happened to have solar keratoses intense erythema developed in and around the keratoses, and in 3 weeks they cleared.2 The drug was then used topically to treat various skin lesions.

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