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Mazindol (teronac) - another anorectic drug


Obesity, its management, and anorectic drugs, have been discussed previously.1 In general our conclusion was and still is that anorectic drugs are better avoided where possible. The success of any weight-reducing regimen depends on reduction of calorie intake: anorectics can help the patient to accept the diet. At present two groups of anorectics are available: non-fluorinated amphetamines such as phentermine (Duromine) and diethylpropion (Apisate; Tenuate)2 which can produce euphoria and are occasionally abused,* and fluorinated amphetamines such as fenfluramine (Ponderax)3 which can induce unacceptable drowsiness during use, and depression during use or after withdrawal.

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  • * Phenmetrazine (Preludin - Boehringer Ingelheim), a non-fluorinated amphetamine, was withdrawn from the UK market in 1972 on account of abuse, but it is still sold in the USA, Canada and elsewhere.