Article Text

Download PDFPDF
The oral hypoglycaemic agents reassessed


The use of hypoglycaemic drugs for the treatment of diabetes mellitus dates from 1955. The two groups of compounds available, the sulphonylureas and the biguanides, have entirely different modes of action in lowering the blood sugar of the diabetic patient. They are used when dietary restriction alone is ineffective in controlling the diabetes and where insulin is not the treatment of choice. They are effective, but an important large trial1 has raised some doubts about their long-term use. The place of these drugs therefore needs to be reassessed.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.