Article Text

Download PDFPDF
Danazol - an inhibitor of gonadotrophin secretion


Danazol (Danol - Winthrop) is a semisynthetic steroid, derived from 17-α-ethinyl testosterone (ethisterone) which inhibits pituitary gonadotropin secretion, probably by inhibiting both synthesis and release. It has no oestrogenic or progestational action but slight anabolic and androgenic activity, and used where suppression of the hypothalemicpituitary-gonadal axis is required without the direct stimulant effects of gonadal steroids. Conditions where this is desirable and where good results have been reported include precocious puberty and some cases of endometriosis, gynaecomastia and pubertal breast hypertrophy.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.