Article Text

Download PDFPDF
Metolazone for hypertension?


Metolazone (Metenix 5 - Hoechst) is a quinazoline sulphonamide diuretic related to quinethazone. We discussed its diuretic properties four years ago (when the trade name was Zaroxolyn)1 and concluded that it was probably more effective than thiazides and had a longer duration of action than frusemide. Metolazone is now also promoted specifically as an antihypertensive diuretic. It is claimed that metolazone is a long-acting ‘extremely effective’ antihypertensive; if this is true it would have an advantage over the thiazide diuretics, which also lower arterial pressure.2

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.