Since we last discussed vitamin D therapy1 the synthetic vitamin D analogue 1α-hydroxyvitamin D3 has become available as alfacalcidol (One-Alpha - Leo). It is recommended for treatment of hypoparathyroidism, renal bone disease, vitamin D-dependent rickets, vitamin D-resistant hypophosphataemic rickets and osteomalacia. Peri-operative treatment is also recommended to reduce the risks of hypocalcaemia after parathyroidectomy.
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