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Beta-blockers - the choice


Eleven β-adrenoceptor blocking drugs are now available in Britain. All share the same basic structure and act by competition at the β-adrenoceptor. We have previously discussed propranolol, oxprenolol, practolol and pindolol,1 2 as well as labetalol which also blocks α-receptors3 and is not dealt with in this article. The others are acebutolol, atenolol, metoprolol, nadolol, sotalol and timolol. Pharmacologically they differ in three ways - their relative capacity to block effects on β1 - (cardiac) and β2 - (lung, blood vessel) adrenoceptors, their local anaesthetic (membrane-stabilising) action, and their partial-agonist (intrinsic sympathomimetic) activity. They also differ in pharmacokinetic properties, convenience and cost. These differences determine the choice.

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