Acetohexamide (Dimelor - Lilly) is a new oral drug for the treatment of diabetes. Like tolbutamide and chlorpropamide, acetohexamide is a sulphonylurea. These lower the blood sugar only when the pancreas can produce some insulin, and they are therefore useful mainly in the treatment of the adult ketosis-resistant diabetic. Acetohexamide, chlorpropamide and tolbutamide in the recommended doses are more or less equally effective. Each is occasionally successful after one of the others has failed1, though there is less experience with acetohexamide because it is newer.
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