Article Text

Download PDFPDF
More on MAO inhibitors and food


We have previously drawn attention to the hypertensive attacks provoked by food substances in patients taking monoamine oxidase inhibitors for the treatment of depression or hypertension (Drug & Therap. Bull. 1963, 1, 44; 1964, 2, 28). Experimental work on patients in America1 has confirmed that tyramine is potentiated up to a hundredfold when given orally or parenterally after a period of amine oxidase inhibition. Analysis of various cheeses1, 2 revealed that cheddar contained more tyramine than well matured varieties such as Camembert and was capable of producing hypertensive crisis in amounts as small as 20 G, thus confirming the earlier clinical reports.3 ECG changes have been reported during attacks and so have large rises in blood pressure of up to 120 mm Hg which may be entirely asymptomatic.4, 7

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.