For five years cimetidine (Tagamet - SKF) has been the only histamine H2-receptor antagonist available for the treatment of peptic ulceration.1 It has now been joined by ranitidine (Zantac - Glaxo), an H2-receptor antagonist which like cimetidine decreases gastric acid secretion both basal and in response to all stimuli.2, 3 Neither drug affects the H1 receptors in bronchial, vascular or intestinal smooth muscle. Is there anything to choose between them?
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