Prostaglandins are involved in the regulation of smooth muscle tone. They may additionally contribute to renal and biliary colic by stimulating secretion in the kidney and gall-bladder, thus raising pressure in the renal and biliary tracts.1,2 Inhibition of prostaglandin synthesis should therefore relieve uteric and biliary spasm and pain. The fastest effects would be expected from an injection of a non-steroidal anti-inflammatory drug (NSAID); an oral or rectal preparation might prolong pain relief. Diclofenac (Voltarol - Ciba-Geigy) is the only NSAID available in Britain as an injection and has recently been licensed for use in renal colic.
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