Abstract

Prostaglandins are involved in the regulation of smooth muscle tone. They may additionally contribute to renal and biliary colic by stimulating secretion in the kidney and gall-bladder, thus raising pressure in the renal and biliary tracts.^1,2 Inhibition of prostaglandin synthesis should therefore relieve uteric and biliary spasm and pain. The fastest effects would be expected from an injection of a non-steroidal anti-inflammatory drug (NSAID); an oral or rectal preparation might prolong pain relief. Diclofenac (Voltarol - Ciba-Geigy) is the only NSAID available in Britain as an injection and has recently been licensed for use in renal colic.