Article Text

Download PDFPDF
▾ Imipenem + cilastatin – a new type of antibiotic


Imipenem is the first of the carbapenems – a new class of β-lactam antibiotics. It is combined with cilastatin, a non-antibiotic enzyme inhibitor which prevents the breakdown of imipenem to nephrotoxic metabolites. The combination (Primaxin – MSD) is available only for intravenous use. Imipenem has an unusually wide spectrum of activity covering most Gram-positive and Gram-negative bacteria including cephalosporin-resistant strains and anaerobes. Empirical use as the sole antibiotic in severe infections and as definitive treatment of unusually resistant bacteria is tempting.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.