Abstract

May & Baker, who have not hitherto marketed an oral diuretic, have now introduced clorexolone (Nefrolan). This drug contains the active radicals present in the thiazides but lacks the benzothiadiazine nucleus. Its pharmacological properties, uses and unwanted actions are those of the thiazides and chlorthalidone. Clorexolone does not significantly inhibit carbonic anhydrase in vivo. Whether, like other oral diuretics, it can cause diabetes mellitus¹ is not yet known.