The treatment of epilepsy is largely empirical. The usual drug of first choice in the treatment of major and of focal epilepsy is phenobarbitone, with or without phenytoin. If the attacks are not satisfactorily controlled, primidone (Mysoline - ICI) may be substituted for phenobarbitone. If after an adequate trial of phenytoin and primidone the epilepsy continues, an additional drug should be given with the other anticonvulsants. Sulthiame (Ospolot - FBA/Bayer Germany) is one of the newer drugs advocated for this purpose.
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