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Methotrexate for rheumatoid arthritis
  • Relevant BNF section: 10.1.3


Treatment of patients with rheumatoid arthritis (RA) conventionally starts with an analgesic plus a non-steroidal anti-inflammatory drug (NSAID). Slow-acting antirheumatic drugs are being added at an increasingly early stage of the disease.1 When we reviewed slow-acting antirheumatics two years ago1 methotrexate had only recently been licensed in the UK for the treatment of RA. In the USA methotrexate is often preferred to traditional slow-acting antirheumatics such as gold, sulphasalazine and penicillamine. We examine the evidence.

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  • Relevant BNF section: 10.1.3

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