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▼Drotrecogin alfa (activated) for severe sepsis
  • Relevant BNF section: 2.11


Sepsis, the systemic inflammatory response to infection, is common among severely ill patients and can be life-threatening. Over a quarter of patients in UK intensive care units (ICUs) have severe sepsis in the first 24 hours after admission.1 Of these, 35% die before leaving the ICU and 47% before leaving hospital despite standard therapy.1 ▼Drotrecogin alfa (activated) (Xigris - Eli Lilly), a recombinant human activated protein C, is licensed for treating adults who have severe sepsis with multiple organ failure. Here we assess its efficacy and safety.

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  • Relevant BNF section: 2.11

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