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Oral or intramuscular vitamin B12?
  • Relevant BNF section: 9.1.2


Vitamin B12 deficiency is common, becoming more so with age, and estimates of its population prevalence have ranged from 1.5% to 15%.1,2 If untreated, it can lead to megaloblastic anaemia and irreversible neurological complications. In the UK, the usual treatment is regular intramuscular injections of hydroxocobalamin.3,4 High-dose oral vitamin B12 replacement is standard practice in some other countries5 and less costly.6 Here we review issues around adopting an oral vitamin B12 replacement regimen more widely in the UK.

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  • Relevant BNF section: 9.1.2

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