Relevant BNF section: BNF 4.3.4
▼Agomelatine (Valdoxan - Servier) is an antidepressant licensed for treating patients with major depressive episodes. The drug company's website for agomelatine states that the drug acts simultaneously as a melatonin receptor agonist and a serotonin receptor antagonist and claims that it is a “major therapeutic advance in management of depression through the restoration of circadian rhythms”.1 Here we consider whether agomelatine offers significant advantage for patients with major depressive episodes.
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