Article Text

Download PDFPDF
Sodium nitroprusside and other reserve drugs for hypertensive emergencies


Sodium nitroprusside was first used in hypertension by Page and his colleagues1 on the basis of previous work in dogs. Its antihypertensive activity is much greater than that of the nitrite ion. The drug directly dilates peripheral arteries. This action does not depend on an intact autonomic nerve supply, and can be demonstrated as well on isolated arteries as in the whole animal.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.