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The success of modern medicine comes with a cost of increased morbidity. Patients are increasingly diagnosed with conditions which, through knowledge gained from randomised controlled trials, we know can be managed successfully with drugs to reduce complications and premature mortality. Multimorbidity is now commonplace, with half of all people aged over 65 years having at least three co-existing conditions, and a fifth having five or more.1 For the patient that might mean 10 or more different drugs to take in the day. Such polypharmacy may be associated with a high risk of interactions, adverse events (17% …

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