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Nalmefene, an opioid modulator, has been available in the UK since 2013 for the reduction of alcohol consumption in adults with alcohol dependence who have a high drinking risk level, without physical withdrawal symptoms and who do not require immediate detoxification.1 It is licensed for use on an as-needed basis with patients advised to take one tablet on days on which they perceive a risk of drinking. Nalmefene has been approved for use by the NHS across the UK.2-4 Following approval in November 2014 by the …