Efficacy and safety of oral treatments for fungal toenail infection have been assessed in a Cochrane review (48 studies, 10,200 participants).¹ Study duration ranged from 4 months to 2 years and participants mainly had subungual fungal infection of the toenails. The review’s authors found that terbinafine was more effective than placebo (8 studies, 1,006 participants) for clinical cure (risk ratio [RR] 6.00, 95% CI 3.96 to 9.08) and mycological cure (RR 4.53, 95% CI 2.47 to 8.33). Azoles (9 studies, …