Chlamydia trachomatis infections during pregnancy are associated with a number of adverse outcomes, including miscarriage and preterm labour. However, treatment choices are limited because several commonly used antibiotics, such as doxycycline, are contraindicated during pregnancy and lactation. An updated Cochrane review has attempted to establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in treating maternal infection and preventing adverse neonatal outcomes.¹

The review (15 trials, 1,754 women) assessed microbiological cure (negative Chlamydia test at least 3 weeks after …