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DOACs and risk of major bleeding with concomitant medicines

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Concurrent use of amiodarone, fluconazole, rifampicin or phenytoin may increase the risk of major bleeding in some patients taking a direct oral anticoagulant (DOAC, also referred to as non-vitamin K [or novel] oral anticoagulant [NOAC]), a retrospective cohort study has found.1

The study included data from 91,330 patients with nonvalvular atrial fibrillation (mean age 75 years) enrolled with the Taiwanese National Health Insurance Administration.1 Patients received at …

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