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A study has analysed the prevalence of off-label use of antidepressants in relation to the level of scientific support for off-label prescribing.1 The study, based in a number of primary care practices in Canada, focused on prescriptions of antidepressants for adult patients between 1 January 2003 and 30 September 2015. The authors highlight problems associated with inefficacious antidepressant prescribing in terms of adverse effects and unnecessary financial costs. The authors note that, although newer-generation antidepressants are considered safer than the older-generation tricyclic antidepressants (TCAs), they are still …