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The injectable monoclonal antibody evolocumab has been shown to reduce low-density lipoprotein (LDL) cholesterol levels by more than 50% in patients with hypercholesterolaemia.1 However, evidence on its effect on cardiovascular events is limited, partly because trials have focussed on a primary outcome of reduction in LDL cholesterol but also as a result of low numbers of cardiovascular events in trials.2,3 A large randomised double-blind placebo-controlled trial has assessed the effectiveness of evolocumab in reducing major cardiovascular events using a composite outcome of cardiovascular death, myocardial infarction, stroke, hospitalisation for unstable angina, or coronary revascularisation.3
The trial (1,272 …