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Gabapentin and risk of severe respiratory depression

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In a recent Drug Safety Update, the Medicines and Healthcare products Regulatory Agency (MHRA) warned about a rare risk of severe respiratory depression with gabapentin, with or without concomitant use of opioids.1 In England, 6.5 million prescriptions for gabapentin were dispensed in 2016.2

A European review of gabapentin was triggered by reports of patients developing respiratory depression without concomitant …

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