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The European Medicines Agency (EMA) has reviewed the safety of retinoids (e.g. acitretin, alitretinoin and isotretinoin) and has recommended updating pregnancy prevention programmes and publishing warnings on the possible risk of neuropsychiatric disorders.1
The review was initiated in 2016 and was performed by the EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) at the request of the UK government.1 The PRAC concluded that all oral retinoids can harm the unborn child and must not be used during pregnancy. In addition, acitretin, alitretinoin and isotretinoin must not …