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Triple inhaled therapy versus dual inhaled therapy for COPD

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Review of: Lipson DA et al. Once daily single-inhaler triple versus dual therapy in patients with COPD. New Engl J Med 2018;378:1671–80.

Key learning points

  • A clinical trial compared single inhaler triple therapy with two forms of single inhaler dual therapy in people with COPD.

  • Ten people would need to be treated with triple therapy instead of LAMA/LABA therapy for 1 year to prevent one moderate or severe exacerbation.

  • Twenty people would need to be treated with triple therapy instead of LAMA/LABA therapy for 1 year to prevent one severe exacerbation.

  • There would be one additional case of pneumonia for every 35 people treated with triple therapy instead of LAMA/LABA therapy for 1 year.

Inhaled triple therapy for chronic obstructive pulmonary disease (COPD) resulted in a reduction in moderate or severe exacerbations and an increase in the risk of pneumonia …

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