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Review of: Lipson DA et al. Once daily single-inhaler triple versus dual therapy in patients with COPD. New Engl J Med 2018;378:1671–80.
Key learning points
A clinical trial compared single inhaler triple therapy with two forms of single inhaler dual therapy in people with COPD.
Ten people would need to be treated with triple therapy instead of LAMA/LABA therapy for 1 year to prevent one moderate or severe exacerbation.
Twenty people would need to be treated with triple therapy instead of LAMA/LABA therapy for 1 year to prevent one severe exacerbation.
There would be one additional case of pneumonia for every 35 people treated with triple therapy instead of LAMA/LABA therapy for 1 year.
Inhaled triple therapy for chronic obstructive pulmonary disease (COPD) resulted in a reduction in moderate or severe exacerbations and an increase in the risk of pneumonia …
Provenance and peer review Commissioned; internally peer reviewed.
Contributors DTB Team.