Article Text

PDF
Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection

Statistics from Altmetric.com

Review of: Blumenthal KG, et al. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ 2018;361:k2400.

Key learning points

  • A record of penicillin allergy was associated with an increased risk of MRSA and Clostridium difficile infection.

  • A record of penicillin allergy resulted in increased use of macrolides, clindamycin and fluoroquinolones.

  • Use of alternatives to beta-lactam antibiotics was associated with an increased risk of MRSA and C. difficile infection.

A matched cohort study found that people with a documented allergy to penicillin have higher rates of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile infection that was influenced by increased use of alternatives to beta-lactam antibiotics.1

Overview

This population matched cohort study used data from an electronic database of 11 million patients registered with UK general practices to …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.