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Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection

https://doi.org/10.1136/dtb.2018.000049

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    Review of: Blumenthal KG, et al. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ 2018;361:k2400.

    Key learning points

    • A record of penicillin allergy was associated with an increased risk of MRSA and Clostridium difficile infection.

    • A record of penicillin allergy resulted in increased use of macrolides, clindamycin and fluoroquinolones.

    • Use of alternatives to beta-lactam antibiotics was associated with an increased risk of MRSA and C. difficile infection.

    A matched cohort study found that people with a documented allergy to penicillin have higher rates of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile infection that was influenced by increased use of alternatives to beta-lactam antibiotics.1

    Overview

    This population matched cohort study used data from an electronic database of 11 million patients registered with UK general practices to …

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    Footnotes

    • Provenance and peer review Commissioned; internally peer reviewed.

    • Contributors DTB Team.