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Review of: Wang H et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev 2018;3:CD006897.
Key learning points
Low-quality evidence confirms previous finding that oral vitamin B12 may be as effective as intramuscular B12 injections for treating deficiency.
High doses of oral vitamin B12 may be better at increasing serum B12 levels, but this was based on a single small study.
The costs of treatment in the oral vitamin B12 group were lower than in the intramuscular group.
There is low-quality evidence that high dose oral vitamin B12 (1–2mg/day) may be as good as intramuscular vitamin B12 with no difference in adverse events.
This update to an earlier Cochrane …
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