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Update on the evidence for oral B12 supplements to treat deficiency

https://doi.org/10.1136/dtb.2018.000057

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    Review of: Wang H et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev 2018;3:CD006897.

    Key learning points

    • Low-quality evidence confirms previous finding that oral vitamin B12 may be as effective as intramuscular B12 injections for treating deficiency.

    • High doses of oral vitamin B12 may be better at increasing serum B12 levels, but this was based on a single small study.

    • The costs of treatment in the oral vitamin B12 group were lower than in the intramuscular group.

    There is low-quality evidence that high dose oral vitamin B12 (1–2mg/day) may be as good as intramuscular vitamin B12 with no difference in adverse events.

    Overview

    This update to an earlier Cochrane …

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    Footnotes

    • Conflict of interest None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.

    • Contributors DTB Team.