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Review of: Li HK, Rombach I, Zambellas R, et al. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med 2019;380:425–36.
Key learning points
Intravenous antibiotics have long been regarded as superior to oral antibiotics for treating complex bone and joint infections.
This trial compared treatment failure rates at 1 year for intravenous and oral antibiotic regimens for orthopaedic infections.
Oral antibiotics were non-inferior to intravenous antibiotics with no difference in the rate of serious adverse events between regimens.
Patients who had oral antibiotics had fewer intravenous-related catheter complications and shorter hospital stays.
For the management of complex bone infections, treatment with oral antibiotics was non-inferior to intravenous antibiotics based on treatment failure rates assessed after 1 year and was associated with a shorter stay in hospital.1
This open-label parallel group randomised controlled non-inferiority trial ('Oral versus Intravenous Antibiotics for bone and joint Infection' [OVIVA]) compared oral and …
Contributors DTB Team.
Provenance and peer review Commissioned; internally peer reviewed.