You are here

Article Text

Article menu
Download PDFPDF
DTB select
Oral or intravenous antibiotics for complex orthopaedic infections?

https://doi.org/10.1136/dtb.2019.000073

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Review of: Li HK, Rombach I, Zambellas R, et al. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med 2019;380:425–36.

    Key learning points

    • Intravenous antibiotics have long been regarded as superior to oral antibiotics for treating complex bone and joint infections.

    • This trial compared treatment failure rates at 1 year for intravenous and oral antibiotic regimens for orthopaedic infections.

    • Oral antibiotics were non-inferior to intravenous antibiotics with no difference in the rate of serious adverse events between regimens.

    • Patients who had oral antibiotics had fewer intravenous-related catheter complications and shorter hospital stays.

    For the management of complex bone infections, treatment with oral antibiotics was non-inferior to intravenous antibiotics based on treatment failure rates assessed after 1 year and was associated with a shorter stay in hospital.1

    Overview

    This open-label parallel group randomised controlled non-inferiority trial ('Oral versus Intravenous Antibiotics for bone and joint Infection' [OVIVA]) compared oral and …

    View Full Text

    Footnotes

    • Contributors DTB Team.

    • Provenance and peer review Commissioned; internally peer reviewed.