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Additional GI bleeding risk with SSRIs in people with declining kidney function

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Review of: Iwagami M et al. Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: a population-based cohort study. Br J Clin Pharmacol 2018;84:2142–51.

Key learning points

  • The use of selective serotonin reuptake inhibitors (SSRI) was associated with an increased risk of gastrointestinal (GI) bleeds.

  • The rate of GI bleeds linked to SSRIs was increased in people with advanced chronic kidney disease.

  • The relative risk of GI bleeding associated with SSRI exposure was around 1.7 regardless of kidney function.

In this cohort study, use of selective serotonin reuptake inhibitors (SSRIs) in people with chronic kidney disease (CKD) was associated with an increase in the risk of gastrointestinal (GI) bleeding.

Overview

This study used the UK Clinical Practice Research Datalink …

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