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Glycopyrronium versus hyoscine for severe drooling

https://doi.org/10.1136/dtb.2019.000002

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    Review of: Parr JR et al. Drooling Reduction Intervention randomised trial (DRI): comparing the efficacy and acceptability of hyoscine patches and glycopyrronium liquid on drooling in children with neurodisability. Arch Dis Child 2017;103:371–6.

    Key learning points

    • Hyoscine patches and glycopyrronium liquid were compared in a 12-week single-blind study in children with neurodisability.

    • There was no statistically significant difference in the mean reduction in Drooling Impact Scale score between the two treatments.

    • More children taking glycopyrronium liquid remained on treatment at 12 weeks compared with those using hyoscine patches.

    Hyoscine patches and glycopyrronium resulted in a similar reduction in severe drooling but by 12 weeks more patients had stopped hyoscine treatment.1

    Overview

    This multicentre single-blind randomised controlled trial compared a hyoscine skin patch with glycopyrronium liquid for the treatment of severe drooling in …

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    Footnotes

    • Provenance and peer review Internally peer reviewed.

    • Contributors DTB Team.