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Glycopyrronium versus hyoscine for severe drooling

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Review of: Parr JR et al. Drooling Reduction Intervention randomised trial (DRI): comparing the efficacy and acceptability of hyoscine patches and glycopyrronium liquid on drooling in children with neurodisability. Arch Dis Child 2017;103:371–6.

Key learning points

  • Hyoscine patches and glycopyrronium liquid were compared in a 12-week single-blind study in children with neurodisability.

  • There was no statistically significant difference in the mean reduction in Drooling Impact Scale score between the two treatments.

  • More children taking glycopyrronium liquid remained on treatment at 12 weeks compared with those using hyoscine patches.

Hyoscine patches and glycopyrronium resulted in a similar reduction in severe drooling but by 12 weeks more patients had stopped hyoscine treatment.1


This multicentre single-blind randomised controlled trial compared a hyoscine skin patch with glycopyrronium liquid for the treatment of severe drooling in …

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  • Provenance and peer review Internally peer reviewed.

  • Contributors DTB Team.