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Is fracture risk linked to gout or urate-lowering therapy?

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Review of: Sultan AA, et al. Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy. CMAJ 2018;190:e581–7.

Key learning points

  • Data from a large observational study have suggested that gout does not increase the risk of vertebral or non-vertebral fractures.

  • Treatment with urate-lowering therapy also had no additional risk or benefit on fracture incidence.

A large prospective observational study that used data from more than 150 000 patients in primary care found that there was no additional risk of fractures in people diagnosed with gout or in people treated with urate-lowering therapy (ULT) for more than 6 months.1


This UK-based study used the Clinical Practice Research Databank database …

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  • Provenance and peer review Commissioned; internally peer reviewed.

  • Contributors DTB Team.