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Which drug treatments are best for trigeminal neuralgia?

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Review of: Yang FMM, et al. Efficacy of 8 different drug treatments for patients with trigeminal neuralgia: a network meta-analysis. Clin J Pain 2018;34:685–90.

Key learning points

  • A comparison of drugs to treat trigeminal neuralgia found carbamazepine, lidocaine and botulinum toxin type A to be more effective than other treatments and placebo.

  • Lidocaine and botulinum toxin type A appeared to give a better response rate than carbamazepine but the reviewers did not take into account the safety profile of the drugs.

  • The analysis was based on a small number of studies and the estimates had large credible intervals, which suggests that the results should be interpreted with caution.

Summary

A network meta-analysis of drugs to treat trigeminal neuralgia found that lidocaine and botulinum toxin type A produced a slightly better response rate than carbamazepine but did not take into …

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