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Review of: Medicines and Healthcare products Regulatory Agency. Hydrochlorothiazide: risk of non-melanoma skin cancer, particularly in long-term use. Drug Safety Update 2018; 12(4): 2.
Key learning points
The Medicines and Healthcare products Regulatory Agency has reported a cumulative, dose-dependent risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in people taking hydrochlorothiazide.
It was estimated that around 9 in 100 SCC cases, 11 in 100 SCC lip cancer cases and fewer than 1 in 100 BCC cases diagnosed during the study periods may be attributed to hydrochlorothiazide use.
Patients taking hydrochlorothiazide-containing products should be informed of the risk of non-melanoma skin cancer and should regularly check for, and report, any new or changed skin lesions or moles.1
The Medicines and Healthcare products …
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