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Comparison of antibiotics for Clostridium difficile infection

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Review of: Beinortas T, et al. Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis. Lancet Infect Dis 2018;18:1035–44.

Key learning points

  • A comparison of 13 drug treatments for Clostridium difficile found high-quality evidence that fidaxomicin was the most effective treatment in providing a long-term cure.

  • Fidaxomicin was a better option than vancomycin for all patients except those with severe infections.

  • Metronidazole was ranked as 11th of 13 drugs in terms of efficacy.

The authors of a network meta-analysis of drugs to treat Clostridium difficile infection have suggested that for non-multiply recurrent infections, fidaxomicin is a better option than vancomycin in all but the most severe infections, and that oral metronidazole …

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