Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Review of Henssler J et al. Trajectories of acute antidepressant efficacy: how long to wait forresponse. J Clin Psychiatry 2018; 79:17r11470.
A systematic review assessed response rates from continuing antidepressant treatment in non-responders.
Analysis of five trials showed a probability of response of around 22% between weeks 5 and 8 compared with 13% with placebo.
Between weeks 8 and 12, the improvement with continued treatment was 10% compared with 2.4% in the placebo group.
In patients with major depressive disorder who did not respond to treatment at 4 weeks, the number-needed-to-treat to achieve a response at 8 weeks with continued treatment, compared with placebo, was 11.1
This systematic review and meta-analysis aimed to estimate how likely it was that people who initially did not respond to antidepressant …
Contributors DTB team.
Provenance and peer review Commissioned; internally peer reviewed.