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How long to wait for a response to an antidepressant?

https://doi.org/10.1136/dtb.2019.000040

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    Review of Henssler J et al. Trajectories of acute antidepressant efficacy: how long to wait forresponse. J Clin Psychiatry 2018; 79:17r11470.

    Key points

    • A systematic review assessed response rates from continuing antidepressant treatment in non-responders.

    • Analysis of five trials showed a probability of response of around 22% between weeks 5 and 8 compared with 13% with placebo.

    • Between weeks 8 and 12, the improvement with continued treatment was 10% compared with 2.4% in the placebo group.

    In patients with major depressive disorder who did not respond to treatment at 4 weeks, the number-needed-to-treat to achieve a response at 8 weeks with continued treatment, compared with placebo, was 11.1

    Overview

    This systematic review and meta-analysis aimed to estimate how likely it was that people who initially did not respond to antidepressant …

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    Footnotes

    • Contributors DTB team.

    • Provenance and peer review Commissioned; internally peer reviewed.