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MHRA drug safety update: risk of Fournier’s gangrene with SGLT2 inhibitors for diabetes

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Review of: Medical and Healthcare products Regulatory Agency. SGLT2 inhibitors: reports of Fournier’s gangrene. Drug Safety Update 2019;12(7):3.

Key learning points

  • Necrotising fasciitis of the genitalia or perineum has been reported in people taking sodium-glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes.

  • If gangrene is suspected, treatment with SGLT2 inhibitors should be stopped and treatment for gangrene (including antibiotics and surgical debridement) started immediately.

  • Urogenital infection or perineal abscess may precede necrotising fasciitis.

Prescribers and patients are …

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  • Contributors DTB Team.

  • Provenance and peer review Commissioned; internally peer reviewed.