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New restrictions and precautions for the use of fluoroquinolones

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Review of: Medicines and Healthcare products Regulatory Agency. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects. Drug Safety Update 2019;12:1.

Key points

  • Very rare but serious adverse events affecting the musculoskeletal and nervous systems have been observed in people taking systemic fluoroquinolones.

  • The most common events were tendonitis, tendon rupture and paraesthesia.

  • At the first sign of tendonitis, treatment with fluoroquinolones should be stopped.

  • Use fluoroquinolones with special caution in people aged over 60 years, people with renal impairment and those who have had solid organ transplants.

Very rare but serious and potentially irreversible adverse effects including tendinopathy and paraesthesia …

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