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Risperidone for rapid tranquilisation: more evidence required

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Review of: Ostinelli EG, Hussein M, Ahmed U, et al. Risperidone for psychosis-induced aggression or agitation (rapid tranquilisation). Cochrane Database of Syst Revs 2018;4: 10.1002/14651858.CD009412.pub2

Key learning points

  • This systematic review assessed whether oral risperidone alone is an effective treatment for psychosis‐induced aggression or agitation.

  • No studies reported on the primary outcome of tranquilisation within 30 min.

  • Very low-quality data for the main outcomes suggested no real effect for oral risperidone.

A lack of evidence for using oral risperidone for rapid tranquilisation has highlighted the need for more clinical trials evaluating oral antipsychotics in the emergency setting.1


This Cochrane review aimed to establish whether oral risperidone alone is an effective treatment for psychosis-induced aggression or agitation.1 Criteria for inclusion in the review included randomised …

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  • Contributors DTB Team.

  • Provenance and peer review Commissioned; Internally peer reviewed.