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Review ofMedicines and Healthcare products Regulatory Agency. Prescribing medicines in renal impairment: using the appropriate estimate of renal function to avoid the risk of adverse drug reactions Drug Safety Update 2019;13(3):3.
Key learning points
Prescribers are reminded to use the most appropriate method of assessing renal function to determine dose adjustments for patients with renal impairment.
Creatinine clearance should be calculated using the Cockroft-Gault formula for some medicines, for older patients and for those with extremes of muscle mass.
Creatinine clearance should always be used to inform dose adjustment for direct-acting oral anticoagulants.
The Medicines and Healthcare products Regulatory Agency (MHRA) has advised prescribers that creatinine clearance (CrCl), calculated using the Cockcroft-Gault formula, is a more appropriate method for assessing impaired …
Contributors DTB Team.
Provenance and peer review Commissioned; internally peer reviewed.