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MHRA guidance on assessing renal function

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Review ofMedicines and Healthcare products Regulatory Agency. Prescribing medicines in renal impairment: using the appropriate estimate of renal function to avoid the risk of adverse drug reactions Drug Safety Update 2019;13(3):3.

Key learning points

  • Prescribers are reminded to use the most appropriate method of assessing renal function to determine dose adjustments for patients with renal impairment.

  • Creatinine clearance should be calculated using the Cockroft-Gault formula for some medicines, for older patients and for those with extremes of muscle mass.

  • Creatinine clearance should always be used to inform dose adjustment for direct-acting oral anticoagulants.

The Medicines and Healthcare products Regulatory Agency (MHRA) has advised prescribers that creatinine clearance (CrCl), calculated using the Cockcroft-Gault formula, is a more appropriate method for assessing impaired …

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  • Contributors DTB Team.

  • Provenance and peer review Commissioned; internally peer reviewed.