You are here

Article Text

Article menu
Download PDFPDF
Editorial
Dapagliflozin for type 1 diabetes: ensuring benefits outweigh the risks
  1. David Erskine, DTB Associate Editor
  1. Department of Pharmacy, Guys & St Thomas NHS Foundation Trust, London, UK
  1. Correspondence to Mr David Erskine, Pharmacy, Guys & St Thomas NHS Foundation Trust, London, UK; david.erskine{at}gstt.nhs.uk

https://doi.org/10.1136/dtb.2019.000081

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Early in 2019, the European Medicines Agency (EMA) extended the licence for dapagliflozin 5 mg tablets to include use by people with type 1 diabetes who have a body mass index (BMI) ≥27 kg/m2 when insulin alone does not provide adequate glycaemic control.1 The National Institute of Health and Care Excellence (NICE) subsequently adjudged dapagliflozin to be a cost-effective option for those with type 1 diabetes who require insulin doses of at least 0.5 units/kg of body weight per day.2 Additional requirements from NICE include the need for a structured education programme about diabetic ketoacidosis (DKA), to have treatment started and supervised by a specialist consultant physician and to stop the drug after 6 months if there is not a sustained improvement in glycaemic control.

    EMA authorisation for type 1 diabetes was based on two placebo-controlled trials …

    View Full Text

    Footnotes

    • Competing interests None declared. Refer to the online supplementary files to view the ICMJE form(s).

    • Provenance and peer review Commissioned; externally peer reviewed.

    • Addendum On 12 February 2020, NICE approved ▼sotagliflozin for use with insulin for people with type 1 diabetes with BMI ≥27 kg/m2. The issues raised in this editorial also apply to the use of sotagliflozin.