Footnotes

• Contributors NS contributed to the writing of the clinical presentation of case 1, as well as the literature review, discussion and review of similar cases. SB contributed to the writing of the clinical course of case 2. DR contributed to the literature review, discussion, including commentary on various mechanisms of action. PO was the principal investigator, and assisted in literature review and provided general supervision of the process, and made several changes which are reflected in the final manuscript.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent for publication Obtained.

• Provenance and peer review Not commissioned; externally peer reviewed.