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Key learning points
Observational evidence suggests that eradication of Helicobacter pylori in patients taking aspirin could reduce the risk of gastrointestinal bleeding.
A UK primary care study evaluated time to first bleeding event in patients taking low-dose aspirin with or without treatment to eradicate H. pylori.
The initial reduction in the rate of peptic ulcer bleeding in the H. pylori eradication group was not sustained throughout follow-up.
The results of a primary care study suggest that H. pylori eradication may provide short-term protection against peptic ulcer bleeding in patients taking low-dose aspirin but the effect was not sustained.1
The Helicobacter Eradication Aspirin Trial (HEAT) was a randomised, double-blind, placebo-controlled study that took place across 1208 UK primary care practices.1 It involved 5352 participants aged ≥60 years (mean age 74 years; 74% men) who had been prescribed aspirin at a dose of ≤325mg daily for at least 4 months …
Contributors DTB Team.
Provenance and peer review Commissioned; internally peer reviewed.