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Editorial
Redaction at the heart of NICE appraisals
  1. James A Cave
  1. The Downland Practice, Berkshire, UK
  1. Correspondence to Dr James A Cave, The Downland Practice, Berkshire, UK; jcave{at}bmj.com

http://dx.doi.org/10.1136/dtb.2023.000035

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    In 2019, the National Institute for Health and Care Excellence (NICE) carried out a technical appraisal of ▼cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma.1 At that time, there was significant uncertainty of the clinical value of the drug—both with regard to its survival data and its cost-effectiveness, but NICE felt it had ‘plausible potential’ and recommended its use within the Cancer Drug Fund. This is an increasingly common practice. A managed access agreement is set up between the NHS and the pharmaceutical company with two key components, namely a data collection arrangement sets out the outcomes that need to be collected to resolve the areas of uncertainty and a commercial agreement sets out (in confidence) the price of the drug during the managed access period.2

    NICE completed its 3-year review of cemiplimab and published an updated technical appraisal in June 2022.3 It approved cemiplimab on the basis that while …

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    Footnotes

    • Competing interests None declared. Refer to the online supplementary files to view the ICMJE form(s).

    • Provenance and peer review Commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.