You are here

Article Text

Article menu
Download PDFPDF
DTB select
Safety update: tramadol-warfarin interaction

https://doi.org/10.1136/dtb.2024.000045

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Key learning points

    • Warfarin has a narrow therapeutic index and many medicines interact with it to increase the risk of bleeding.

    • A coroner investigated the case of a patient who died from bleeding in the brain following the concomitant use of warfarin and tramadol.

    • The Medicines and Healthcare products Regulatory Agency has highlighted an increased risk of major bleeding when warfarin and tramadol are used together.

    In June’s Drug Safety Update, the Medicines and Healthcare products Regulatory Agency (MHRA) included details of the risk of an increased international normalised ratio (INR) and the potential for major bruising and bleeding when warfarin and tramadol are taken concomitantly.1

    Overview

    The MHRA published an article in its Drug Safety Update …

    View Full Text

    Footnotes

    • Contributors DTB Team.

    • Provenance and peer review Commissioned; internally peer reviewed.