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VTE risk with concomitant use of hormonal contraception and NSAID

https://doi.org/10.1136/dtb.2024.000046

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    Key messages

    • Some hormonal contraceptives and non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a risk of venous thromboembolism (VTE).

    • A Danish cohort study examined data for 2 million women to assess VTE risk of concomitant use of hormonal contraception and an NSAID.

    • Use of an NSAID with hormonal contraception was associated with a small increased risk of VTE and the level of risk varied across different types of contraceptives.

    A Danish observational study of more than 2 million women found a small increased risk of venous thromboembolism (VTE) associated with concomitant use of a non-steroidal anti-inflammatory drug (NSAID) and some hormonal contraceptives.1

    Overview

    This Danish nationwide cohort study analysed patient-level and prescription-level data for 2 029 065 women aged 15–49 years between 1996 and 2017 with median follow-up of 10 years.1 …

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    Footnotes

    • Contributors DTB Team.

    • Provenance and peer review Commissioned; internally peer reviewed.